Armpje drukken: aanval de beste verdediging?

Inleiding Humerusschachtfracturen kunnen veroorzaakt worden door een direct trauma, een val op de gebogen elleboog of hand met uitgestrekte arm of door een plotselinge rotatiebeweging. Een direct trauma resulteert meestal in een dwarse fractuur. Een plotselinge rotatiebeweging resulteert vaak in een spiraalfractuur in het bijzonder in het distale deel van de humerus. ‘Armpje drukken’ of ‘arm worstelen’ is een bezigheid die door jong volwassen mannen veelvuldig op recreatief, maar ook op competitief niveau wordt beoefend. Toch is deze activiteit minder onschuldig dan het in eerste instantie lijkt

Spatial and Dynamic Modeling of Flood Management Policies in the Upper Tisza

Flood management policy has been the subject of an international joint research project with the Upper Tisza in Hungary as its pilot study area. Design specifications for a geographically explicit simulation are presented. Potential flood management policies, based on surveys and interviews with stakeholders, are presented. Some experiments on an executable prototype of the simulation model are also reported on, where the consequences of flood management policies are investigated. Focus has been on financial policy measures, mainly insurance. Besides more traditional evaluation of policy scenarios, the model incorporates adaptive optimization functionality. The report incorporates three contributions: (1) the insurance policy issue in Hungary is framed in the broader context of flood management; (2) the structuring of a flood risk policy model, capable of simulating flood failures and estimating the economic consequences; (3) reports from policy experiments performed on the implemented prototype flood risk policy model

Production of human recombinant proapolipoprotein A-I in Escherichia coli: purification and biochemical characterization

A human liver cDNA library was used to isolate a clone coding for apolipoprotein A-I (Apo A-I). The clone carries the sequence for the prepeptide (18 amino acids), the propeptide (6 amino acids), and the mature protein (243 amino acids). A coding cassette for the proapo A-I molecule was reconstructed by fusing synthetic sequences, chosen to optimize expression and specifying the amino-terminal methionine and amino acids -6 to +14, to a large fragment of the cDNA coding for amino acids 15-243. The module was expressed in pOTS-Nco, an Escherichia coli expression vector carrying the regulatable X P^ promoter, leading to the production of proapolipoprotein A-I at up to 10% of total soluble proteins. The recombinant polypeptide was purified and characterized in terms of apparent molecular mass, isoelectric point, and by both chemical and enzymatic peptide mapping. In addition, it was assayed in vitro for the stimulation of the enzyme lecithin: cholesterol acyltransferase. The data show for the first time that proapo A-I can be produced efficiently in E. coli as a stable and undegraded protein having physical and functional properties indistinguishable from those of the natural product

Flood Risk Management Policy in the Upper Tisza Basin: A System Analytical Approach. Simulation and Analysis of Three Flood Management Strategies

This report describes an integrated flood catastrophe model as well as some results of a case study made in the upper Tisza region in northeastern Hungary: the Palad-Csecsei basin (the pilot basin). The background data was provided through the Hungarian Academy of Sciences and complemented by interviews with different stakeholders in the region. Based upon these data, where a large degree of uncertainty is prevailing, we demonstrate how an implementation of a simulation and decision analytical model can provide insights into the effects of imposing different policy options for a flood risk management program in the region. We focus herein primarily on general options for designing a public-private insurance and reinsurance system for Hungary. Obviously, this is a multi-criteria and multi-stakeholder problem and cannot be solved using standard approaches. It should however be emphasized that the main purpose of this report is not to provide any definite recommendations, but rather to explore a set of policy packages that could gain a consensus among the stakeholders

Determination of rat vertebral bone compressive fatigue properties in untreated intact rats and zoledronic-acid-treated, ovariectomized rats

Summary: Compressive fatigue properties of whole vertebrae, which may be clinically relevant for osteoporotic vertebral fractures, were determined in untreated, intact rats and zoledronic-acid-treated, ovariectomized rats. Typical fatigue behavior was found and was similar to that seen in other species. Fatigue properties were comparable between both groups. Introduction: Osteoporosis is often treated with bisphosphonates, which reduce fracture risk. Effects of bisphosphonates on fatigue strength, which may be clinically relevant for vertebral fractures, are unknown. We determined vertebral, compressive fatigue properties in normal and zoledronic acid (ZOL)-treated, OVX rats. Methods: Thirty-five-week old Wistar rats were divided into SHAM-OVX (n = 7) and OVX with ZOL treatment (n = 5; single injection, 20 μg/kg b.w. s.c.). After 16 weeks, vertebral trabecular microarchitecture and cortical thickness were determined using micro-CT. Vertebrae were cyclically compressed in load-control at 2 Hz starting at 0.75% apparent strain. A line parallel to the apparent strain curve was drawn at 0.5% higher offset, after which the intersection was defined as the time to failure and the apparent strain at failure. Data were compared using Student’s t test.Results Morphology and fatigue properties were the same in both groups. Samples failed between 10 min and 15 h. Force–displacement curves displayed typical fatigue behavior. Displacement increased over time due to mostly creep and to decreasing secant stiffness. Conclusions: We established a technique to determine compressive fatigue properties in the rat vertebral body. Our initial results indicate that ZOL-treated OVX rats have similar vertebral fatigue properties as SHAM-OVX controls

Third-party responses to injustice: a review on the preference for compensation

People are often confronted with injustice that is done to others. In such cases, observers (i.e. third-parties) of injustice can restore justice by punishing the perpetrator, as shown by a vast amount of research. However, this focus on punishment has led to the neglect of another behavioural option: compensation of the victim. The current review focuses on this latter behavioural option. More specifically, it is argued that third-parties are more compensation-oriented than previous literature appears to demonstrate. To support this argument, previous research is discussed and the factors that might explain observers’ preference for compensation are outlined. To conclude, suggestions for future research are presented.Criminal Justice: Legitimacy, accountability, and effectivit